anti yap (Cell Signaling Technology Inc)
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Cell Signaling Technology Inc
anti yap
Anti Yap, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 98/100, based on 1491 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/anti+yap/YAP+XP+Rabbit+mAb/pm42894734-264-38-40
Average 98 stars, based on 1491 article reviews
Anti Yap, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 98/100, based on 1491 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/anti+yap/YAP+XP+Rabbit+mAb/pm42894734-264-38-40
Average 98 stars, based on 1491 article reviews
anti yap - by Bioz Stars,
2026-10
98/100 stars
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Magnetic Beads:Article Title: Inflammatory macrophages drive smooth muscle dedifferentiation via YAP signaling in murine deep vein thrombosis. Article Snippet: Cells were lysed in Pierce IP Lysis Buffer (Thermo Scientific, 87787) and coimmunoprecipitation experiments were performed using SureBeads magnetic beads (Biorad, 1614013) as per the manufacturer’s protocol. .. In brief, Protein A magnetic beads were washed in TBST, incubated with Incubation:Article Title: Inflammatory macrophages drive smooth muscle dedifferentiation via YAP signaling in murine deep vein thrombosis. Article Snippet: Cells were lysed in Pierce IP Lysis Buffer (Thermo Scientific, 87787) and coimmunoprecipitation experiments were performed using SureBeads magnetic beads (Biorad, 1614013) as per the manufacturer’s protocol. .. In brief, Protein A magnetic beads were washed in TBST, incubated with Article Title: Neuronal and Glial YAP/TAZ in the Spinal Cord Contribute to the Development of Bone Cancer Pain in Mice. Article Snippet: The treatment of bone cancer pain (BCP) remains a major clinical challenge, and the mechanisms underlying BCP remain poorly understood.. Here, we report that tumor cell implantation (TCI) led to nuclear accumulation of yes-associated protein (YAP) and transcriptional coactivator with PDZ (postsynaptic density protein 95, PSD95; discs large, Dlg; zonula occludens-1, ZO-1)-binding motif (TAZ) and up-regulation of their mRNA (messenger ribonucleic acid) expression in Vglut2+ excitatory neurons, microglia, and astrocytes in the spinal dorsal horn.. Pharmacological inhibition of YAP/TAZ or genetic knockout of YAP/TAZ in Vglut2+ excitatory neurons, microglia, or astrocytes significantly alleviates TCI-induced BCP. Article Title: Inflammatory macrophages drive smooth muscle dedifferentiation via YAP signaling in murine deep vein thrombosis. Article Snippet: .. The membranes were blocked with 5% skim milk, and incubated overnight at 4 °C with the following primary antibodies: anti-Phospho-YAP (Ser127) (13008, Cell Signaling Technology; 1:1000), Article Title: Injectable mRNA-engineered short fibers deliver temporally coupled mechano-genetic signals to reprogram Schwann cell cytoskeleton for nerve repair. Article Snippet: .. Sections were blocked with 5% BSA and incubated with primary antibodies overnight at 4 ◦C: anti-c-Jun antibody (9165S, CST, Danvers, MA), anti-S100β (90393, CST, Danvers, MA), anti-GAP43 antibody (87287-1-RR, Proteintech, Wuhan, China), anti-CD31 antibody (3528S, CST, Danvers, MA), Control:Article Title: Inflammatory macrophages drive smooth muscle dedifferentiation via YAP signaling in murine deep vein thrombosis. Article Snippet: Cells were lysed in Pierce IP Lysis Buffer (Thermo Scientific, 87787) and coimmunoprecipitation experiments were performed using SureBeads magnetic beads (Biorad, 1614013) as per the manufacturer’s protocol. .. In brief, Protein A magnetic beads were washed in TBST, incubated with Binding Assay:Article Title: Neuronal and Glial YAP/TAZ in the Spinal Cord Contribute to the Development of Bone Cancer Pain in Mice. Article Snippet: The treatment of bone cancer pain (BCP) remains a major clinical challenge, and the mechanisms underlying BCP remain poorly understood.. Here, we report that tumor cell implantation (TCI) led to nuclear accumulation of yes-associated protein (YAP) and transcriptional coactivator with PDZ (postsynaptic density protein 95, PSD95; discs large, Dlg; zonula occludens-1, ZO-1)-binding motif (TAZ) and up-regulation of their mRNA (messenger ribonucleic acid) expression in Vglut2+ excitatory neurons, microglia, and astrocytes in the spinal dorsal horn.. Pharmacological inhibition of YAP/TAZ or genetic knockout of YAP/TAZ in Vglut2+ excitatory neurons, microglia, or astrocytes significantly alleviates TCI-induced BCP. other:Article Title: Adaptable sliding hydrogels enable pericellular pocket formation while enhancing MSC chondrogenesis and survival in 3D Article Snippet: After PBS washing, samples were blocked for 30 min and then incubated overnight in primary antibody overnight at 4 °C at a 1:100 dilution (Abcam 34712, Abcam 34710, and Thermo Scientific 14-9771-82). Article Title: From disease model to therapeutic insight: An engineered hydrogel reveals the role of matrix viscous dissipation in intervertebral disc degeneration Article Snippet: Inhibitors in cell culture were used at the following concertation: 0.25 μM VP to inhibit YAP (MCE, China, CL 318952), 10 μM PF-573228 (MCE, China, HY-10461) to inhibit p-FAK, 1 μg ml −1 ITGB 1-blocking antibody (Abcam, NBP2-16974), VBIT-4 (MCE, China, HY-129122) to inhibit mitochondria damage and SN-011 (MCE, China, HY-145010) to inhibit STING. Immunofluorescence:Article Title: Integrin‐Binding Matricellular Protein Fibulin‐5 Maintains Epidermal Stem Cell Heterogeneity During Skin Aging Article Snippet: .. Immunofluorescence staining was performed as previously described (Xuan Ngo et al. ) using the following primary antibodies: rabbit Staining:Article Title: Integrin‐Binding Matricellular Protein Fibulin‐5 Maintains Epidermal Stem Cell Heterogeneity During Skin Aging Article Snippet: .. Immunofluorescence staining was performed as previously described (Xuan Ngo et al. ) using the following primary antibodies: rabbit |
![Q209R preferentially engages <t>FAK‐YAP</t> signaling. (A) Western blot analysis of GNAQ, BAP1, Melan‐A, p‐ERK1/2 (Thr202/Tyr204), ERK1/2, FRA1, p‐AKT (Ser473), AKT, <t>p‐4EBP1</t> <t>(Ser65),</t> and 4EBP1 expression in mouse UM cell lines harboring GNAQ Q209R or GNAQ Q209L . HSP90 was used as an internal loading control. (B) Quantification of the relative ratio between p‐AKT (Ser473) and AKT in Q209R and Q209L UM cell lines from (A). (C) Quantification of the relative ratio between p‐4EBP1 (Ser65) and 4EBP1 in Q209R and Q209L UM cell lines from (A). (D) Western blot analysis of p‐FAK (Tyr397), FAK, p‐YAP (Ser127), and YAP in mouse UM cell lines harboring GNAQ Q209R or GNAQ Q209L . HSP90 was used as an internal loading control. (E) Quantification of the relative ratio between p‐FAK (Tyr397) and FAK in Q209R and Q209L UM cell lines from (D). (F) Quantification of the relative ratio between p‐YAP (Ser127) and YAP in Q209R and Q209L UM cell lines from (D). Orthotopic tumor‐derived cell lines (QBM12.1 [Q209R], QBM12.3 [Q209R], QBM24 [Q209R], QBM45 [Q209L], QBM47 [Q209L]) and liver metastatic lines (QBM12L [Q209R], QBM12L2 [Q209R], QBM51L [Q209L], QBM53L [Q209L]) were used in A–F. (G) Representative IHC images showing YAP expression in primary tumors from Gnaq CA ; Bap1 CKO ; Myc CKI mice harboring either GNAQ Q209R or GNAQ Q209L . (H) Quantification of the nuclear‐to‐cytoplasmic YAP intensity ratio (H‐score) among primary tumors from Gnaq CA ; Bap1 CKO ; Myc CKI mice harboring either GNAQ Q209R or GNAQ Q209L . (I) Representative IHC images showing YAP expression in liver metastasis derived from intrasplenic transplantation of mouse UM cell lines harboring GNAQ Q209R or GNAQ Q209L . (J) Quantification of nuclear YAP intensity (H‐score) among liver metastasis derived from intrasplenic transplantation of mouse UM cell lines harboring GNAQ Q209R or GNAQ Q209L .](https://pub-med-central-images-cdn.bioz.com/pub_med_central_ids_ending_with_5764/pmc13635764/pmc13635764__PCMR-39-0-g001.jpg)
